Alpha thalassemia is caused by alpha-globin gene deletion which results in reduced or absent production of alpha-globin chains. However, her Mentzer Index (the quotient of the corpuscular volume divided by the RBC count) of 14.4 is suggestive of iron-deficiency anemia. It is used to distinguish between two types of microcytic anemia: a value greater than 14 suggests iron deficiency anemia; a value less than 13 suggests thalassemia. Ein Mentzer-Index von weniger als 13 weist auf eine Diagnose der Beta-Thalassämie hin, während ein Wert von mehr als 13 auf einen Eisenmangel hindeutet. Alpha Thalassemia. Mentzer’s Index • If CBC shows microcytic anemia, ratio of MCV/RBC can distinguish iron deficiency from thalassemia. Methods: This study was a prospective study done on 30 patients each of thalassemia trait and iron deficiency anemia (Total 60 patients). Keywords: anemia, mentzer index, RDW index, thalesemia. The Mentzer index is defined as mean corpuscular volume per red blood cell count. The most commonly used formulas are the following: Mentzer index (MI) = MCV/RBC; discriminant factor (DF) = MCV × (RDW/Hb × 100); Shine and Lal Index (S&L) = MCV × (MCH/100); Srivastava Index (SI) = MCH/RBC; RDW index (RDWI) = (MCV × RDW)/RBC. The Mentzer index, described in 1973 by William C. Mentzer, is the MCV divided by the RBC count. Die Symptome der α-Thalassämie entstehen in der Folge einer verringerten Herstellung bestimmter Globinketten. Die Differentialdiagnostik der Thalassämie umfasst andere Ursachen einer hypochromen mikrozytären Anämie, insb.. Eisenmangelanämie; Angeborene sideroblastische Anämie; Siehe auch: Diagnostik der Anämie AMBOSS erhebt für die hier aufgeführten Differentialdiagnosen keinen Anspruch auf Vollständigkeit. RDW index has highest positive predictive value (90.91%), while Green and King index has highest negative predictive value (98.87%). Alpha globin gene has 4 alleles and disease severity ranges from mild to severe depending on the number of deletions of the alleles. Mentzer index; Purpose: in differentiating iron deficiency anemia from beta thalassemia: The index is calculated from the results of a complete blood count. Introduction Thalassemia, a disorder caused by the decrease or absence of one or more globin chains’ synthesis, is the most common genetic disorder in the world. Sie nimmt bei Homozygoten einen sehr schweren… MENTZER INDEX(M.I)= <13 SEEN IN THALASSEMIA AND >13 IN … Dies führt zu einer schweren Anämie, die regelmäßige Bluttransfusionen erforderlich machen kann.… Beta-Thalassaemia major (Cooley-Anämie): Mehr zu Symptomen, Diagnose, Behandlung, Komplikationen, Ursachen und Prognose lesen. Alpha-Thalassämie: Die Thalassämie ist eine autosomal-rezessiv vererbte hämolytische Anämie. Im Vorfeld kann bereits durch den Mentzer-Index abgeschätzt werden, ob es sich eher um eine Eisenmangelanämie oder eine Beta-Thalassämie handelt. A Mentzer index of less than 13 suggests that the patient has the thalassemia trait, and an index of more than 13 suggests that the patient has iron deficiency. Beta thalassemias are due to mutations in the HBB gene on chromosome 11, also inherited in an autosomal, recessive fashion. African descent (2% Incidence) Asian patients (Incidence common) Beta Thalassemia Youden index which tells about the overall performance of a diagnostic test was highest for Kerman 1 index (65.4%). The individuals having thalassemia trait usually have asymptomatic course &have mild microcytic High diagnostic accuracy in distinguishing Thalassemia with iron deficiency anemia was RDW index (88.14%), and followed by Mentzer index (86.85%). Differentialdiagnosen. Alpha thalassemia major with hemoglobin Bart's usually results in fatal hydrops fetalis. Bei der α-Thalassämie sind zwei Gene namens HBA1 und HBA2 betroffen, die zur Manifestation der Krankheit führen. Mentzer index of more than 13 was shown to be predictive of ID, meanwhile a value less than 13 favours thalassemia trait (17). World wide: 1.7% (4.4 per 10,000 live births) Among at risk ethnicities: 5-30%; Ethnicity. Online mentzer index calculator ✅. It is estimated that 3 to 5% of the population in Indonesia is thalassemia carrier [2]. Alpha thalassemia is usually caused by a deletion of one or more of the alpha globin genes, leading to a decrease in alpha chain production and a relative excess of beta chains. Mentzer-Index. S Afr Med J 2015; 105:702. gleda p baldini January 7, 2020 at 7:34 pm - Reply To Tapesh and Licia. Similarly, no RBC index is good enough to diagnose thalassemia trait but Mentzer Index is best and most easily calculated among the broadly available formulae that can be used reliably in screening. Bei der α-Thalassämie handelt es sich um eine spezielle Form der Thalassämie. Die Beta-Thalassämie major ist die schwerste Form von Beta-Thalassämie, gekennzeichnet durch eine völlige Abwesenheit von Beta-Globinketten im Hämoglobin. • < 13 beta thalassemia more likely (thalassemia is a disorder of globin synthesis, normal amount of cells, but cells produced are smaller and more fragile, RBC Mentzer index ( MCV in fL / RBC in millions per microliter ) if less than 13 is suggestive of thalassemia while more than 13 is seen in IDA. The aim of our study was to evaluate the reliability of Mentzer index in the differentiation of iron deficiency anemia and Thalassemia trait. An index of less than 13.0 suggests that the patient has thalassemia trait, and an index of more than 13.0 is indicative of iron deficiency anemia. The percentage of correctly diagnosed cases was the highest for Red Cell Distribution Width Index (RDWI) (84.19%) followed by Mentzer Index (86.85%). Use this simple medical calculator ✅ to calculate mentzer index using mentzer index values. S Afr Med J 2015; 105:702. Keywords: Mentzer Index, diagnostic value, thalassemia 1. Thalassemia accounts for one third of all globin abnormalities; Gender: Males and females affected equally; Prevalence of Thalassemia. Mentzer index, England and Fraser index, RDW index and Ehsani index each, showed highest specificity (99.66% each). Thalassämie und Kinderwunsch Es ist wichtig, dass Menschen mit Thalassämie informiert sind über die Vererbungsmöglichkeit und die damit verbundenen Risiken. តាម Mentzer’s Index អាចអេាយយេីងគិតថា ជា thalassemia។ នេះជាអ្វីដែរត្រូវធ្វេីបន្ទាប់។ លទ្ធចេញមកគឺគាត់អាចមាន alpha thalassemia អាចជា minor form បេីតាម clinical and history ( … Mentzer indeks(MI) dapat membantu membedakan defisiensi besi dengan thalassemia dimana pemeriksaan ini merupakan hasil perhitungan MCV/RBC.Bila hasil perhitungan >14 ( suggestive) indikasi anemia defisiensi besi, namun bila <12 (suggestive) indikasi thalassemia trait. Alpha thalassemia intermedia, or hemoglobin H disease, causes hemolytic anemia. Objective: Thalassemia trait is commonly seen in Indian population especially in certain communities like Sindhis, Kachchis, Gujaratis& Bengalis. It is said to be helpful in differentiating iron deficiency anemia from beta thalassemia.. the Mentzer index (MCV/red blood cell count) can help distinguish between iron deficiency and thalassemia. Bildgebende Untersuchungen sind notwendig, um das Vorhandensein von Komplikationen, insbesondere … If the quotient of the mean corpuscular volume (MCV, in fL) divided by the red blood cell count (RBC, in Millions per microLiter) is less than 13, thalassemia is said to be more likely. mentzer index(m.i)mentzer index(m.i) m.i =m.i = <13 seen in thalassemia<13 seen in thalassemia andand >13 in iron deficiency anemia>13 in iron … Alpha thalassemia trait Minor anemia 3 Hemoglobin H disease Mild to moderate anemia may lead normal life 4 Hydrops fetalis Fetal death usually occurs at birth Beta-thalassemia. Mentzer index: (ments′ĕr) The mean corpuscular volume divided by the red blood cell count (in millions). [Determination of the diagnostic value of erythrocyte discrimination indices (Mentzer and Srivastava) and of glycerol lysis time (GLT 50) in microcytosis]. Mentzer index could be used to predict the diagnosis of beta-thalassemia carrier. Mentzer Index sensitivity (Sn) was 0.36 with specificity (Sp) at 0.81, positive predictive value (PPV) at 0.44 and negative predictive value (NPV) at 0.75. Mentzer Index sensitivity (Sn) was 0.36 with specificity (Sp) at 0.81, positive predictive value (PPV) at 0.44 and negative predictive value (NPV) at 0.75. Mentzer index and RDW is a test that is widely used by clinicians to differentiating early screening of Thalassemia with iron deficiency anemia. Mentzer Index (MI) MI > 13 eher Eisenmangel MI < 13 eher Beta-Thalassämie Wird im Labor ein Eisenmangel nach- gewiesen, kann eine Thalassämie erst nach erfolgter Korrektur des Eisen-mangels ausgeschlossen werden. Iron deficiency anemia Beta thalassemia major & intermedia Sickle thalassemia Hb H disease Red cell Fragmentation syndromeAnemia with high RDW 72. Mentzer index OR value was 2.4 (0.5 - 11.5, CI95%). WHO reported that 5% of the world’s population is thalassemia carriers [1]. There are nondeletional forms of alpha thalassemia, which may be more severe than deletional forms, but these are less common. Mentzer index is such an index. Use of the Mentzer index will assist in early diagnosis of iron deficiency in South African children. The only 2 input parameters include Mean corpuscular volume (MCV) and Red Blood cell count (RBC count) which is available in CBC report.This App will give you a fair idea about the presumptive diagnosis. Mentzer index calculator can give a fair idea of diagnosis on the basis of a simple complete blood count report. Bruccoleri F, Zepponi E, Balucanti F, et al. 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